Abstract
We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure. He had pulmonary tuberculosis, accepted isoniazid, rifampin, ethambutol, pyrazinamide and rifampicin. He developed tics on both sides of the face. Surprisingly, he was also found the bilateral symmetrical frontal lobe and dentate nucleus hyperintensities on T2-weighted and T2 FLAIR MR imaging. After excluding other causes, INH induced neurological side effect was suspected so the drug was stopped, pyridoxine was added and hemoperfusion was applicated. Tics disappeared after 1 week.
Highlights
INH is a first-line drug for anti-tuberculosis, and the therapeutic dose rarely causes adverse reactions
We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure
The patient was a known case of end stage renal failure (ESRD) secondary to diabetic nephropathy and hypertension, and was on regular hemodialysis three times per week for the last one year
Summary
INH is a first-line drug for anti-tuberculosis, and the therapeutic dose rarely causes adverse reactions. The patient was a known case of end stage renal failure (ESRD) secondary to diabetic nephropathy and hypertension, and was on regular hemodialysis three times per week for the last one year. He was diagnosed as pulmonary tuberculosis 3 months before this admission, and was treated with. He presented with bad mental state, severe anemia countenance and severe pitting edema on his double lower limbs. On day 7 after the adjustment of anti-tuberculosis therapy, the tics disappeared completely
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