Abstract
Letters and Corrections1 December 1978Isoniazid and Antinuclear AntibodiesOSVALDO HÜBSCHER, M.D., OSVALDO GARCÍA-MORTEO, M.D., ROBERT M. ARANA, M.D.OSVALDO HÜBSCHER, M.D.Search for more papers by this author, OSVALDO GARCÍA-MORTEO, M.D.Search for more papers by this author, ROBERT M. ARANA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-1011_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rothfield, Bierer, and Garfield state in a recent issue (1) that isoniazid alone or in combination is a potent inducer of antinuclear antibodies (ANA); in their prospective study 22% of 102 tuberculosis patients developed ANA after at least 1 month of treatment. In a prospective study, Siegel, Lee, and Peress (2) found no evidence of an increase of ANA after prolonged isoniazid therapy in 29 patients, but this result was regarded as inconclusive because of the small sample size.We have found ANA by indirect immunofluorescence in 6% of 80 isoniazid-treated tuberculosis patients at a mean dose...
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