Isomerization of an Enantiomerically Pure Phosphorus-Bridged [1]Ferrocenophane

Abstract

The enantiomerically pure phospha[1]ferrocenophane 4-C1 was prepared through a salt-metathesis reaction between tBuPCl2 and a chiral dilithioferrocene derivative (Li2fc3-Pen), which was equipped with two 3-pentyl groups in α positions with respect to lithium on the Cp rings (Sp,Sp isomer; C2 symmetry). The chiral 4-C1 isomerizes in reaction mixtures to give the Cs-symmetrical phospha[1]ferrocenophane 4-Cs. This thermal isomerization involves haptotropic η5 to η1 shifts of Cp rings and is catalyzed by the chelating ligand 1,1′-(tBuClP)2fc3-Pen, which is a byproduct of the salt-metathesis reaction. Both phospha[1]ferrocenophanes, 4-C1 and 4-Cs, were isolated and characterized as pure compounds; the molecular structure of 4-Cs was determined by a single-crystal X-ray analysis. According to DFT calculations, the equilibrium constant K° for 4-C1 ⇌ 4-Cs is 4.43 (ΔESCF = −3.74 kcal/mol; ΔH° = −3.81 kcal/mol; ΔG° = −3.68 kcal/mol). As deduced from calculated molecular geometries, the thermodynamic difference betw...