Abstract
Treatment of hematoporphyrin IX dimethyl ester (7) with tetrapropylammonium perruthenate (Pr{sup n}{sub 4}N)(RuO{sub 4}) and N-methylmorpholine N-oxide affords a high yield of the separable monoacetylmono(1-hydroxyethyl)-deuteroporphyrin isomers 5 and 6. Proton NMR NOE experiments and chemical transformations involving specific individual deuteration at the 1- and 3-methyls and 2- and 4-vinyls are used to characterize the isomers.
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