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Abstract
Seven new butanolides, peltanolides A–G (1–7), and two lignan glucosides, peltasides A (8) and B (9), along with eleven known compounds, 10–20, were isolated from a crude CH3OH/CH2Cl2 (1:1) extract of the fruit of Hernandia nymphaeifolia (Hernandiaceae). The structures of 1–9 were characterized by extensive 1D and 2D NMR spectroscopic and HRMS analysis. The absolute configurations of newly isolated compounds 1–9 were determined from data obtained by optical rotation and electronic circular dichroism (ECD) exciton chirality methods. Butanolides and lignan glucosides have not been isolated previously from this genus. Several isolated compounds were evaluated for antiproliferative activity against human tumor cell lines. Lignans 15 and 16 were slightly active against chemosensitive tumor cell lines A549 and MCF-7, respectively. Furthermore, both compounds displayed significant activity (IC50 = 5 µM) against a P-glycoprotein overexpressing multidrug-resistant tumor cell line (KB-VIN) but were less active against its parent chemosensitive cell line (KB).
Highlights
IntroductionPlants in the genus Hernandia (Hernandiaceae) are found in subtropical and tropical areas [1]
Plants in the genus Hernandia (Hernandiaceae) are found in subtropical and tropical areas [1].They contain diverse bioactive secondary metabolites, especially lignans, including podophyllotoxin analogues [2,3], and benzylisoquinolines [4], including aporphines [5,6,7]
Compounds 1, 2, 8, 10, and 13–18 were evaluated for antiproliferative effects against five human tumor cell lines, A549, MCF-7, MDA-MB-231, KB, and P-glycoprotein (P-gp)-overexpressing multidrug-resistant (MDR) KB subline, KB-VIN (Table 4)
Summary
Plants in the genus Hernandia (Hernandiaceae) are found in subtropical and tropical areas [1]. H. nymphaeifolia (C.Presl) Kubitzki (synonym: H. peltata Meisn.) is a common coastal tree and grows to 12–20 m in height This plant has been used for the treatment of abdominal. H. nymphaeifolia (C.Presl) Kubitzki (synonym: H. peltata Meisn.) is a of 16 antibacterial activities common coastal tree and grows to 12–20 m in height. This plant has been used for the treatment of abdominal pains, boils, cough, diarrhea, eye problems, and convulsions as a traditional medicine in pains, boils, cough, diarrhea, eye problems, and convulsions as a traditional medicine in western western Samoa [11].
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