Isolation, Purification and Structure Elucidation of a Xanthone from the Pericarp of Kamandiis (Garcinia rubra Merr.)

Cherry Mae T Ravidas,Teofila D.C Villar,Hidelisa P Hernandez,Leon O Namuco

doi:10.26534/kimika.v30i1.40-44

Abstract

The pericarp of Garcinia rubra, an endemic Garcinia species in the Philippines was extracted with dichloromethane. An isolate of the extract was acetylated giving monoacetyl and diacetyl derivatives. Analysis of these derivatives led to the elucidation of the xanthone 1,3,7-trihydroxy-2,4-bis(3-methylbut-2-enyl)-9H-xanthen-9-one. The compound was isolated and characterized through column chromatography, acetylation, FTIR, NMR and LCMS analyses.

Highlights

Garcinia species have been known as ayurvedic plants in Southeast Asia to treat diseases such as dysentery, diarrhea and many others (Werayut and Wandee, 2008)
The Garcinia species found in the Philippines include G. binucao or batuan in Panay island, G. mindanaensis or kariis in Bukidnon, G. venulosa or gatasan in Luzon, G. vidalii or piris which is found in Benguet, G. dulcis or takláng-anák which is found from Luzon to Mindanao and the Malay Peninsula, G. benthami which is found in Palawan, G. rubra or kamandiis, and G. mangostana in some parts of the Philippines (Pelser et al, 2011)
Only few have been subjected to studies regarding isolation of bioactive compounds which include G. mangostana (Itoh et al, 2008), G. dulcis (Deachathai et al, 2005) and G. benthami (Nguyen et al, 2011)

Summary

Introduction

Garcinia species have been known as ayurvedic plants in Southeast Asia to treat diseases such as dysentery, diarrhea and many others (Werayut and Wandee, 2008). Only few have been subjected to studies regarding isolation of bioactive compounds which include G. mangostana (Itoh et al, 2008), G. dulcis (Deachathai et al, 2005) and G. benthami (Nguyen et al, 2011). This study reports the isolation, purification and structure elucidation of a xanthone from the pericarp of G. rubra. Extensive examination of literature on Garcinia does not include reports on isolation of bioactive compounds from G. rubra.

Results

Conclusion