Abstract
Two new phenolic glucosides, pipercroside A and B (1 and 2), along with 10 known compounds were isolated from the leaves of Piper crocatum Ruiz & Pav. Their chemical structures were elucidated through extensive spectroscopic analyses, including 1D and 2D NMR experiments and HR-ESI-MS analysis and comparison with previously reported data. All the isolated compounds were assessed for soluble epoxide hydrolase (sEH) inhibitory activity. Among them, erigeside II (5) showed inhibitory activity with an IC50 value of 58.5 µM.
Highlights
The genus Piper belongs to the Piperaceae family and comprises around 700 species distributed across both hemispheres [1]
Soluble epoxide hydrolase is widely distributed in mammalian tissue, with potent effects on the biological activities conducted by the cardiovascular and urinary systems [8]. It is responsible for the hydrolysis of epoxyeicosatrienoic acids (EETs), which are endothelium-derived hyperpolarizing factors (EDHFs) that act as regulators of vascular function [9]
The soluble epoxide hydrolase (sEH) enzyme is widely distributed in mammalian tissue, with potent effects on the on the biological activities conducted by the cardiovascular and urinary systems [8]
Summary
The genus Piper belongs to the Piperaceae family and comprises around 700 species distributed across both hemispheres [1]. Apart from being widely used as common food adjuncts as flavoring, seasoning, coloring agents, and preservatives, spices are known to have a variety of antioxidant effects and properties [2] In this regard, many plants are used for therapeutic purposes as exceptional sources of phytochemicals such as phenolic compounds [3]. Soluble epoxide hydrolase (sEH) is widely distributed in mammalian tissue, with potent effects on the biological activities conducted by the cardiovascular and urinary systems [8]. It is responsible for the hydrolysis of epoxyeicosatrienoic acids (EETs), which are endothelium-derived hyperpolarizing factors (EDHFs) that act as regulators of vascular function [9].
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