Abstract
Pelvic ligaments of guinea pigs undergo very pronounced relaxation during pregnancy to facilitate the birth of young. While studying the physiology of this reaction, one of us discovered that it was under hormonal control and that the substance responsible was present in the blood of certain mammals during pregnancy.1 This hormone is capable of producing relaxation of the pelvic ligaments of virgin guinea pigs in a fashion typical of pregnancy, if given while the animals are in or recovering from oestrum. Later it was found that this reaction could also be produced through the use of extracts of corpora lutea of sows' ovaries. General methods for the preparation of these extracts have been given elsewhere.2 These corpus luteum extracts, in addition to relaxing the pelvic ligaments, also produced other physiological changes ordinarily attributed to the corpus luteum, such as inhibition of ovulation, vacuolation of the vaginal mucosa of rats,3 production of pseudo-pregnancy in rabbits,4 and production of pr...
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