Abstract
Dipeptidyl peptidase-IV (DPP-IV) is a protease responsible for the degradation of the incretin hormone. A number of DPP-IV inhibitors have been approved for use in the treatment of type 2 diabetes. While these inhibitors are effective for this treatment, methods for the prevention of this disease are also required as diabetes patient numbers are currently increasing rapidly worldwide. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. Rose (Rosa gallica) bud extract powder was a promising material with high inhibitory activity. In this study, seven ellagitannins were isolated as active compounds through activity-guided fractionations, and their DPP-IV inhibitory activities were measured. Among them, rugosin A and B showed the highest inhibitory activities and rugosin B was shown as the major contributing compound in rose bud extract powder.
Highlights
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Q'sai Co., Ltd., Kusagae, Fukuoka, Fukuoka 810-8606, Japan
The action of Dipeptidyl peptidase-IV (DPP-IV) is a normal bodily response to stop the overworking of glucagon-like peptide 1 (GLP-1), its inhibition is currently used as a method to treat type 2 diabetes mellitus (T2DM) patients
The isolation of DPP-IV inhibitors was accomplished by activity guided fractionations
Summary
Laboratory of Food Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Q'sai Co., Ltd., Kusagae, Fukuoka, Fukuoka 810-8606, Japan. We screened the DPP-IV inhibitory activities of edible plant extracts with the intention of using these extracts in a functional food supplement for the prevention of diabetes. The action of DPP-IV is a normal bodily response to stop the overworking of GLP-1, its inhibition is currently used as a method to treat type 2 diabetes mellitus (T2DM) patients. A variety of anti-diabetes medicine, including DPP-IV inhibitors have been developed and succeed in maintaining patients’ blood glucose levels to prevent associated diseases like diabetic neuropathy, the numbers of T2DM patients are consistently increasing every year. We screened edible plant extracts for DPP-IV inhibitory activity, with the aim of using these extracts in a T2DM preventing food supplement, and found rose (Rosa gallica) bud extract powder as a promising material. We report the isolation, structure elucidation, and activities of DPP-IV inhibitors from rose bud extract powder
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