Abstract

1. 1. Extracts of acetone powders of human placental or bovine liver “mitochondria” in the presence of bovine adrenal “mitochondrial” particles catalyze steroid 11β-hydroxylation 1. The extracts have been subjected to (NH 4) 2SO 4 fractionation, Sephadex G-100 gel filtration and DEAE-cellulose column chromatography, and fractions active in supporting 11β-hydroxylation were isolated and compared with adrenodoxin isolated from bovine adrenal “mitochondria”. 2. 2. The placental and liver DEAE-cellulose fractions did not have significant absorbence in the 400–700 nm region nor did they contain nonheme iron or acid-labile sulfur although their Chromatographic properties were similar to adrenodoxin.

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