Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Kyoung Jin Park,Dong Hyun Kim,Chung Sub Kim,Joonseok Oh,Lalita Subedi,Mi Won Son,Sang Zin Choi,Sun Yeou Kim,Kang Ro Lee

doi:10.1016/j.tetlet.2018.10.057

Isolation of indole alkaloid and anthranilic acid derivatives from Indigo Pulverata Levis

Kyoung Jin Park, Dong Hyun Kim + Show 7 more

https://doi.org/10.1016/j.tetlet.2018.10.057

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Journal: Tetrahedron Letters	Publication Date: Oct 25, 2018
Citations: 9

Affiliation: Sungkyunkwan University, Gachon University, Yale University, Dong-A Pharmaceutical (South Korea), Dong-A ST (South Korea)

#Anthranilic Acid Derivatives #Induction Of Nerve Growth Factor + Show 8 more

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Abstract

A new indole alkaloid, pulveratinol (1), and two new anthranilic acid derivatives (2 and 3) were isolated from Indigo Pulverata Levis, together with 12 known compounds (4–15). The structures of the new compounds (1–3) were determined through spectroscopic methods. The absolute configuration of 1 was confirmed further by electronic circular dichroism (ECD) data analysis and computational method with advanced statistics (DP4). All isolated compounds (1–15) were evaluated for their potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.

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