Abstract

Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle.

Highlights

  • Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia

  • Isolation of the ancestral Dengue virus (DENV)-1 after >30 years suggests that a mosquito–host transmission cycle has maintained this virus

  • The original ancestral dengue virus type 1 (DENV-1) isolate P72_1244 was designated as sylvatic because it was isolated from a sentinel monkey in a rural forest [3]

Read more

Summary

Isolation of Ancestral Sylvatic

Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle. DENV-1 was the predominant virus isolated and accounted for 68% of all DENVs isolated This outbreak represented a third cycle that involved DENV-1 in Malaysia since the 1960s [7].

Year isolated
Conclusions
Findings
Serum group*

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.