Abstract
Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle.
Highlights
Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia
Isolation of the ancestral Dengue virus (DENV)-1 after >30 years suggests that a mosquito–host transmission cycle has maintained this virus
The original ancestral dengue virus type 1 (DENV-1) isolate P72_1244 was designated as sylvatic because it was isolated from a sentinel monkey in a rural forest [3]
Summary
Ancestral sylvatic dengue virus type 1, which was isolated from a monkey in 1972, was isolated from a patient with dengue fever in Malaysia. The virus is neutralized by serum of patients with endemic DENV-1 infection. Rare isolation of this virus suggests a limited spillover infection from an otherwise restricted sylvatic cycle. DENV-1 was the predominant virus isolated and accounted for 68% of all DENVs isolated This outbreak represented a third cycle that involved DENV-1 in Malaysia since the 1960s [7].
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