Abstract
Cells have developed a highly integrated system responsible for proteome stability, namely the proteostasis network (PN). As loss of proteostasis is a hallmark of aging and age-related diseases, the activation of PN modules can likely extend healthspan. Here, we present data on the bioactivity of an extract (SA223-S2BM) purified from the strain Salinispora arenicola TM223-S2 that was isolated from the soft coral Scleronephthya lewinsohni; this coral was collected at a depth of 65 m from the mesophotic Red Sea ecosystem EAPC (south Eilat, Israel). Treatment of human cells with SA223-S2BM activated proteostatic modules, decreased oxidative load, and conferred protection against oxidative and genotoxic stress. Furthermore, SA223-S2BM enhanced proteasome and lysosomal-cathepsins activities in Drosophila flies and exhibited skin protective effects as evidenced by effective inhibition of the skin aging-related enzymes, elastase and tyrosinase. We suggest that the SA223-S2BM extract constitutes a likely promising source for prioritizing molecules with anti-aging properties.
Highlights
Accepted: 9 December 2021Aging is characterized by a time-dependent decline in functional capacity and stress resistance, as well as by increased mortality and morbidity rates [1]
Proteome integrity is maintained by the proteostasis network (PN), which extends to all subcellular compartments and is regulated at the cellular, tissue and organismal level in order to ensure organismal health and longevity [7]
The targeted microbial strain was isolated from the coral S. lewinsohni, which is a soft coral endemic to the Red Sea
Summary
Accepted: 9 December 2021Aging is characterized by a time-dependent decline in functional capacity and stress resistance, as well as by increased mortality and morbidity rates [1]. Proteome integrity is maintained by the proteostasis network (PN), which extends to all subcellular compartments and is regulated at the cellular, tissue and organismal level in order to ensure organismal health and longevity [7]. Sustaining proteostasis requires cells to coordinate and regulate the functions of synthesis, folding, sorting, transport, and degradation of all polypeptides [8,9]. These cellular functions are mostly carried out by three major interconnected branches of PN, namely the network of molecular chaperones, the ubiquitin proteasome-(UPP), and autophagy lysosome-(ALP) proteolytic pathways [10,11]
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