Abstract
A new phenalenone derivative, 2,4,6,9-tetrahydroxy-7-methyl-2-prenyl-1 H-phenalene-1,3(2 H)-dione (1), was isolated from the ethyl acetate extract of a marine-derived Penicillium sp. fungus that exhibited a unique antimicrobial activity profile. The planar structure of 1 was determined through a combination of 1D and 2D NMR experiments, and circular dichroism and polarimetry indicated that it was isolated as a racemic mixture of enantiomers. The antimicrobial activity of 1 was assessed against a panel of gram-positive and gram-negative bacteria and fungal strains, and it was found to selectively inhibit the growth of Staphylococcus aureus and Mycobacterium tuberculosis.
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