Abstract
The plant Papaver rhoeas ,which belongs to family Papaveraceae and known as common poppy is wildly grown in Iraq .It was used in traditional medicine in wide range of diseases including inflammation, diarrhea, sleep disorders, treatment of cough, analgesia, and also to reduce the withdrawal signs of opioid addiction.
 The project provide the first comprehensive research done in Iraq to study the phytochemical and the methods of extraction and separation of alkaloids from Papaver rhoeas wildly grown in Iraq .The plant was harvested in April 2019 from Zurbatiya is an Iraqi town located at the northeast of Waist province in Iraq.The collected plant was washed thoroughly, dries under shade, and grounding in a mechanical grinder to fine powder. The plant was extracted by hot extraction method using Methanol then fractionation was done to separate alkaloids from chloroform Fraction by TLC and PTLC .The alkaloids were isolated and purified by PTLC then subjected to various analytical techniques for alkaloids identification such as UV, LC mass and IR .The result was indicated of three alkaloids (dihydrocodien, chelidonine and papaverrubine C) in Papaver rhoeas plant.
Highlights
Poppy (Papaver rhoeas L.) figure 1 is a temperate native with a very wide distribution area, from Africa to temperate and tropical Asia andEurope[1]
It grows up to about 70 cm (28 in) in height 2).The stems hold single which are large and showy, 5–10 cm (2–4 in) across with four petals that are vivid red, most commonly with a black spot at their base[3].The plant has been used for medicinal proposes a long time ago for treatment of a wide range of diseases including inflammation, diarrhea, sleep disorders, treatment of cough, analgesia, and to reduce the withdrawal signs of opioid addiction [4]it is known to claim intestinal and urinary irritation and to be useful in various conditions such as bronchitis, pneumonia, and rash[5]
The data obtained from IR, UV, LC/MS of the isolated compound B were identical with the Data of papaverrubine C (Epiporphyroxine), which indicate that compound B could be papaverrubine C (Epiporphyroxine) which is Rhoeadines/ papaverrubines type of alkaloids[16,17]
Summary
Poppy (Papaver rhoeas L.) figure 1 is a temperate native with a very wide distribution area, from Africa to temperate and tropical Asia andEurope[1]. It grows in fields, beside roads, and on Grassland .Papaver rhoeas is a variable, erect annual, forming a long-lived soil seed bank that can germinate when the soil is disturbed. Pharmacological studies have shown that the plant extract may have some radical scavenging properties[6].Investigations indicated that the Papaver rhoeas extract possess properties of anti-ulcer genic [7], Antinociception [8], anti in flammatory effect [9] and Stress amelioration effect [10]. This study was conducted for identification of alkaloids that extracted from Papaver rhoeas
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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