Abstract
Objective: The aim of the present investigation is to isolate actinomycetes from the sediments of Pichavaram mangrove forest, South India, and to screen for their antibacterial efficiency.
 Methods: Actinomycetes were isolated by culturing the samples in Starch Casein Agar medium; they were screened primarily for their antibacterial efficiency against Gram-positive and Gram-negative bacterial organisms. Solvent extraction was done with 50% (percentage) ethyl acetate, crude extracts of actinomycetes were prepared at different concentrations using dimethyl sulfoxide and treated against the bacterial organisms. Antibacterial assay was done in Mueller–Hinton agar medium.
 Results: Thirteen actinomycetes were isolated; among them, four actinomycete isolates (Pichavaram mangrove actinomycete 2 [PMA2], PMA6, PMA9, and PMA13) exhibited antibacterial activity.
 Conclusion: Isolate PMA2 exhibited very strong antibacterial activity and isolate PMA13 is weakly active against the tested bacterial organisms.
Highlights
Coastal region is an important region for human beings since the beginning of time
The study was aimed to screen antibacterial efficiency by producing bioactive natural compounds from the actinomycetes isolated from the sediments of Pichavaram Mangrove Forest, South India
Salinity test To find TDS, 100 ml of water sample was evaporated in a hot air oven
Summary
Coastal ecosystem supports coral reefs, seagrasses, marine biota, and the growth of mangrove forest. Mangroves are the most important ecosystems of coastal and marine region. Bioactive molecules are capable of modulating metabolic process and they exhibit beneficial effects such as antioxidant activity, inhibition or induction of enzymes, inhibition of receptor activities, and induction and inhibition of gene expression. They are useful for the protection mechanism [1]. The study was aimed to screen antibacterial efficiency by producing bioactive natural compounds from the actinomycetes isolated from the sediments of Pichavaram Mangrove Forest, South India
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