Abstract
In contrast with the Schmidt-Ruppin strain of RSV, Bryan strains are not oncogenic for ducks. From the Bryan standard strain (BS-RSV) a variant virus oncogenic for ducks was isolated by passing BS-RSV through cortisone-treated ducklings together with chick embryonic tissues. From the Bryan high titer strain (BH-RSV) such a variant virus could not be isolated. The variant virus (BK-RSV) is also oncogenic for mice and hamsters, whereas parent strain lacks such oncogenicity for mammals. Thus, there may be some correlation between oncogenicity for ducks and mammals. Mouse or hamster tumors induced by the BK strain did not produce infectious RSV eitherin vivo orin vitro. However, when hamster tumor cells in appropriate amounts were inoculated in the wing web of chickens, sarcomas were induced yielding infectious RSV. Thus, the RSV genome persists in BK-induced mammalian tumor cells and is able to produce infectious virus in the presence of chicken cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
