Abstract
The DNA of the European wildcat ( Felis sylvestris) contains sequences which hybridize to [ 3H]DNA transcripts of the RNA of domestic cat type C viruses of the RD-114/CCC group. To determine if the sequences could code for the production of infectious virions, tissues from a European wildcat were cocultivated with established cell lines from heterologous species known to be permissive for the replication of endogenous domestic cat type C viruses. Both a syncytium-forming (“foamy”) and a type C virus were isolated, and the type C viral component was resolved by passaging the mixed virus stock in cells which are relatively resistant to infection by feline syncytium-forming viruses. The European wildcat type C virus (FS-1) is highly related to viruses of the RD-114/CCC group by viral host range and interference critera. FS-1 contains a reverse transcriptase and major group-specific protein (p30) with antigenic determinants similar to those of the homologous proteins of RD-114, and [ 3H]DNA transcripts of FS-1 RNA hybridize extensively to the RNA of endogenous domestic cat type C viruses. Like viruses of the RD-114/CCC group, FS-1 is related by several criteria to endogenous baboon type C viruses. The results indicate that European wildcats contain endogenous type C virogenes which can code for the production of infectious type C particles.
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