Abstract
In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
Highlights
Fungi produce a vast range of secondary metabolites [1]
We report the isolation and structure elucidation of a new natural product (1) and the screening for bioactive compounds of fungal crude extracts
(n = 4); -: No inhibition zone measured; * Dichloromethane (DCM) extracts. Both ethyl acetate and methylene chloride (DCM) extracts of X. psidii (KT30) and strain KT31 showed antifungal activity, DCM extracts were less active than the EtOAc extracts
Summary
Fungi produce a vast range of secondary metabolites [1]. Some of these are high-value products with pharmaceutical applications such as penicillins [2]. Marine fungi are believed to be prolific resources of natural products [3,4,5,6]. Their potential has not yet been fully investigated. Marine fungi comprise of an estimated 1500 species, excluding those that form lichens [8]. This number is low compared to the number of described and estimated terrestrial fungi (over 250,000) [9]. We report the isolation and structure elucidation of a new natural product (1) and the screening for bioactive compounds of fungal crude extracts
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