Abstract
THE F9 antigen, defined by antisera raised in syngeneic mice against pluripotent embryonal carcinoma cells, is present on early mouse embryos, spermatozoa and male germinal cells, but not on adult somatic tissues1,2. This antigen, thought to be coded by gene(s) located at, or linked to, the developmentally important T/t complex, may play a part in early embryogenesis3–5. This idea is supported by the fact that the antigen seems to have been conserved during mammalian evolution. Anti-F9 activity is absorbed by sperm of several species including man, rat, rabbit and bull5–7 and there is evidence for its presence on the morulae of rabbit, rat and cow, and on human foetal testicular cells2,5. The cross reaction of anti-F9 with human sperm suggested that undifferentiated stem cells in human teratocarcinomas might also carry F9 on their surface, and we report here the isolation of human teratocarcinoma cell line which expresses F9 antigen.
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