Abstract
cDNAs encoding human family-IV phosphodiesterase, subtype D (hPDE IV D) were isolated from a human heart cDNA library. The overlapping cDNAs encode a polypeptide of 604 amino acids (aa) with a predicted 0 M r of 68 502, which is 91.4% identical to the rat homolog, rPDE IV D. hPDE IV D produced in Escherichia coli was inhibited by rolipram. Expression of the hPDE IV D mRNA is widespread in human tissues and most abundant in skeletal muscle.
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