Abstract
Abstract o-Toluenesulfonamide (o-TS) was found to be a major impurity in 9 of 10 different saccharin samples used for carcinogenicity tests in animals in various laboratories. Isolation of o-TS from sodium saccharin was achieved by extraction with ethyl acetate, and separation was accomplished by using thin layer chromatography. Saccharin samples obtained in the free acid form were first converted to their sodium salts. o-TS was identified by Rf and ultraviolet, infrared, and mass spectra. Quantitative determination of o-TS was performed by gas chromatography. The concentration of o-TS in the samples ranged from 2.5 to 5050 ppm.
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