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Abstract
BackgroudFoot-and-mouth disease virus (FMDV) serotype Asia1 generally infects cattle and sheep, while its infection of pigs is rarely reported. In 2005-2007, FMD outbreaks caused by Asia1 type occurred in many regions of China, as well as some parts of East Asia countries. During the outbreaks, there was not any report that pigs were found to be clinically infected.ResultsIn this study, a strain of FMDV that isolated from pigs was identified as serotype Asia1, and designated as "Asia1/WHN/CHA/06". To investigate the genomic feature of the strain, complete genome of Asia1/WHN/CHA/06 was sequenced and compared with sequences of other FMDVs by phylogenetic and recombination analysis. The complete genome of Asia1/WHN/CHA/06 was 8161 nucleotides (nt) in length, and was closer to JS/CHA/05 than to all other strains. Potential recombination events associated with Asia1/WHN/CHA/06 were found between JS/CHA/05 and HNK/CHA/05 strains with partial 3B and 3C fragments.ConclusionThis is the first report of the isolation and identification of a strain of FMDV type Asia1 from naturally infected pigs. The Asia1/WHN/CHA/06 strain may evolve from the recombination of JS/CHA/05 and HNK/CHA/05 strains.
Highlights
Foot-and-mouth Disease is a highly contagious and economically important disease of cloven-hoofed animals, predominantly for cattle, sheep, and pigs
In 2005-2007, FMD outbreaks caused by Asia1 type occurred in many regions of China, as well as some parts of East Asia countries
Hemolysis occurred in the mixtures containing Foot-and-mouth disease virus (FMDV) O and A type positive serums, whereas the mixtures containing FMDV Asia1 type positive serums didn’t show any virtual change
Summary
Foot-and-mouth Disease is a highly contagious and economically important disease of cloven-hoofed animals, predominantly for cattle, sheep, and pigs. There are seven immunologically distinct serotypes of the virus, namely types O, A, C, SAT1, SAT2, SAT3 and Asia, and subtypes have been found within some serotypes [1]. FMD serotype Asia has been epidemic in China for more than 50 years. This serotype usually infects cattle and sheep, and its infection of pigs is seldom reported [2]. In 2005-2007, FMD outbreaks caused by Asia type occurred in many regions of China, as well as some parts of East Asia countries. There was not any report that pigs were found to be clinically infected [2]
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