Abstract
A study of the metabolic alteration of pyridine-2-aldoxime methiodide (PAM) in man has involved analysis of human urine following the oral administration of the drug to healthy volunteers. This report describes the isolation of the intact drug and a fluorescent metabolite of it from human urine. From preliminary chemical, ultraviolet and infrared spectral studies it is concluded that: (1) the metabolite is a highly polar molecule; (2) it possesses a carboxyl function and a weakly acidic, ionizable group; and (3) it is not a conjugate of glycine or glucuronic acid, and it is not an oxime. Spectral behavior of the metabolite of PAM, in comparison with known pyridine derivatives, suggests that it is a derivative of N-methyl picolinic acid.
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