Isolation, Characterization, Chemical Modification and Application of Echinochloa Colona Starch as Tablet Disintegrant

Abstract

Oral disintegrating tablets are solid dosage form containing medical substances which disintegrate rapidly, usually within few seconds when placed upon tongue requiring no additional water to facilitate swallowing. Solid dosage forms that can be disintegrated, dissolved, or suspended by saliva in the mouth resulting in easy swallowing can provide significant benefits to the pediatric and geriatric population, as well as other patients who prefer the convenience of easily swallowable dosage forms Superdisintegrants are currently approached and utilized in the formulation of the orally disintegrating tablets. The present work includes isolation of starch from Echinochloa Colona and further characterizing it for various physicochemical and phytochemical analysis. The isolated starch has been modified chemically and its disintegrating efficiency has been tested in tablet formulation; the present work also explores the optimization of concentration of starch in formulation of Ibuprofen tablets in comparison with synthetic and natural superdisintegrants. Phytochemical analysis confirmed the presence of starches and carbohydrates. Results indicated that the Echinochloa Colona starch samples could be potential superdisintegrants in orally disintegrating tablets of Ibuprofen. Tablet performance was found to influence by the way of addition of starch, its concentration and the method of tablet preparation. From these results it is possible to conclude that Echinochloa Colona starch could be used as a superdisintegrant.