Abstract
Pavona sp. is highly spread over Indonesian waters including Panjang Island. Several studies showed that bacteria symbionts hardcoral were the big source of antibiotic product, but there was limited research of the bacteria symbionts with hardcoral Pavona sp. In this research bacteria symbionts from hardcoral Pavona sp. had been collected from Panjang Island, Jepara. Marine bacteria symbionts were isolated by serial dillution method, while antibacterial activity was performed by using overlay and agar block method. The total of 2 from 5 isolates were active to MDR bacteria such as Enterobacter aerogenes and Acinetobacter baumanii, the code were PHC 44/04 and PHC 44/05. Then both of them were identified by morphological and molecular DNA characterization using 16 S rRNA gene sequence. The result of 16 S rRNA identification shows PHC 44/04 has 99% similarities with Virgibacillus salarius strain sa-Vb 1, while PHC 44/05 shows 99% similarities with Pseudoalteromonas flavipulchra strain NCIMB 2033.
Highlights
Staphylococcus haemolyticus infection is commonly occurred in the hospital as a nosocomial infection and related to implanted medical devices [1][2]
This was supported by a statement from [15] and [16] that the microorganisms associated with macroorganisms have a symbiotic relationship with its specific host, so the fungus associated with soft corals can be used as a sustainable source of bioactive compounds because they grow faster than macroorganisms
The infection due to MDR-S. haemolyticus associated with implanted medical devices has a significant impact especially in expense for hospitalized patients
Summary
Staphylococcus haemolyticus infection is commonly occurred in the hospital as a nosocomial infection and related to implanted medical devices [1][2]. This bacteria include in a gram positive, non-spore forming, non-motile, facultative anaerobic bacteria. S. haemolyticus has the highest level of antimicrobial resistance among all CoNS species [10] Based on this evidence, the exploration of new anti-MDR S. haemolyticus agent should be investigated in order to develop new therapy. A new approach to obtain a sustainable source and answer the scarcity of source is marine-derived fungi isolated from soft corals. The objective of this research may serve a pioneer of antibacterial agent with sustainable source and may provide the information to a pharmaceutical industry about marine natural product that is environmental friendly
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