Isolation and studies on chemotherapeutic potential of aloin

Abstract

Background: Plant‑derived phytochemicals are gaining wide popularity owing to their diverse therapeutic potential and less side‑effects. Aloin is one of the plant‑derived flavonoids. Rutin has demonstrated cardioprotective, analgesic, and anticancer effects. Aim: The current work was focused to evaluate bioactive potential of aloin. Materials and Methods: Aloin was isolated from tobacco leaves. The structure was confirmed by H1 NMR spectroscopy. The isolated aloin was studied for possible antibacterial, antifungal, anthelmintic, larvicidal, and cytotoxic effects. Statistical Analysis Used: The results are expressed as mean ± standard error of the mean. Experiments were always performed in triplicates. Statistical comparison was performed using analysis of variance followed by Bonferroni’s test (*P < 0.05). Results and Conclusions: Results of studies demonstrated that rutin effectively inhibited the growth of bacteria and fungi, as well as it also demonstrated the anthelmintic potential. There was a positive response for larvicidal and cytotoxic effects. These studies justify chemotherapeutic potential of aloin. Key words: Aloin, antibacterial, antifungal, anthelmintic, larvicidal, cytotoxic