Isolation and structure of the human cancer cell growth inhibitory cyclic decapeptides phakellistatins 7, 8 and 9 1,2

Abstract

Phakellistatins 7–9 respresent the first cancer cell growth inhibitory (P388 ED 50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides. Each was isolated from the Federated States of Micronesia (Chuuk) marine sponge Phakellia costata. The Federated States of Micronesia (Chuuk) marine sponge Phakellia costata has been found to contain (10 −5 and 10 −6% yields) three cancer cell line active (P388 ED 50 3.0, 2.9 and 4.1 μg/mL respectively) cyclic decapeptides named phakellistatins 7 ( 1), 8 ( 2) and 9 ( 3). Phakellistatins 7–9 represent the first cancer cell growth inhibitory cyclic decapeptides isolated from a marine sponge.