Abstract
Lolitrem A, the second most abundant minor lolitrem in endophyte-infected perennial ryegrass, has been isolated and its structure determined by mass spectrometry and one- and two-dimensional NMR spectroscopy. Lolitrem A, which other workers have suggested to be 7α-hydroxylolitrem B, was found to be an inseparable mixture of the 44R and 44S isomers of 44,45-epoxylolitrem C. An assignment of the methyl group proton and carbon resonances of lolitrem B is also reported. The intensity and time course of the tremorgenic activity of lolitrem A in mice were identical to that of lolitrem B.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
