Abstract
Isolation and structural characterization of novel thermal degradation impurity of nafcillin sodium using spectroscopic and computational techniques
Highlights
Nafcillin sodium (NS) is a parenteral, second generation penicillinase-resistant penicillin antibiotic used largely to treat moderate to severe staphylococcal infections
Characterization of thermal degradation impurity (TDI) Mass structural characterization studies LC–MS analysis indicated the presence of protonated ions [M+H]+ of TDI and NS drug substance at m/z 688.42 Da and 415.26 Da respectively
HRMS data indicated that the molecular ions [M+H]+ of TDI and [M+Na]+ of NS at m/z 688.2343 Da and 437.1152 Da (Table 1)
Summary
Nafcillin sodium (NS) is a parenteral, second generation penicillinase-resistant penicillin antibiotic used largely to treat moderate to severe staphylococcal infections. Characterization of TDI Mass structural characterization studies LC–MS analysis indicated the presence of protonated ions [M+H]+ of TDI and NS drug substance at m/z 688.42 Da and 415.26 Da respectively.
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