Abstract
Trichorzins PA are new members of the class of natural Aib-containing peptides, which are known under the common name peptaibols. They are produced by a Trichoderma harzianum strain and exhibit significant activity against mycoplasmas. From the natural peptide mixture, seven trichorzins PA (PA II and IV–IX) have been isolated by a procedure employing different chromatography steps and a final purification by reversed-phase HPLC. The amino acid sequence elucidation involved a combination of liquid secondary-ion mass spectrometry (LSIMS) and two-dimensional 1 H and 13 C NMR spectroscopy. Trichorzins PA are 18-residue peptaibols which differ mainly from other, related peptides by the C-terminal amino alcohol which is either tryptophanol or phenylalaninol. They adopt a helical structure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Chemical Society, Perkin Transactions 1
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
