Abstract
Summary Objective To study the antimicrobial activity of fungi isolated from Brazilian cerrado soil. Material and methods A total of 200 fungal strains were isolated from soil samples collected from Serra do Cipo National Park in Brazil. Antibacterial activity against Escherichia coli , Staphylococcus aureus , Salmonella typhimurium , Streptococcus pyogenes and Listeria monocytogenes was screened. Results Around 67% of the extracts showed activity against at least one of the tested bacteria. Thirteen isolates, selected as the most common species found in the studied soil samples (over 50% of all isolates), were microscopically identified as Chaetomium cupreum, Curvularia senegalensis, Fusarium oxysporum, Penicillium citrinum, Penicillium janthinellum, Penicillium paxilli, Penicillium sclerotiorum, Penicillium simplicissimum, Penicillium waksmanii, Rhizopus stolonifer, Syncephalastrum racemosum, Trichoderma koningii and Trichoderma reesei . Large scale experiment proved positive antibacterial results for Penicillium sclerotiorum and Penicillium simplicissimum , since bioactive metabolites (sclerotiorin, isochromophilone VI, pencolide and penicillic acid) were recovered from their fermentation in preparative scale. Conclusion Cerrado soil fungi constitute another important source of antibiotics producing micro-organisms that can be further exploited as source of lead compounds for anti-infective agents industry.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
