Abstract
Abstract An enzyme which catalyzes the reduction of aromatic α-keto acids to phenyllactic acids has been isolated from beef and dog heart. This enzyme has been designated aromatic α-keto acid reductase. Reduced diphosphopyridine nucleotide is a required cofactor for aromatic α-keto acid reductase activity. Substrates for aromatic α-keto acid reductase include 3,5-diiodo-p-hydroxyphenylpyruvic acid, p-hydroxyphenylpyruvic acid, and phenylpyruvic acid. 3,5-Diiodo-p-hydroxyphenylpyruvic acid has a high affinity for the enzyme (Km of 4.3 x 10-5 m). The enzyme is present in many mammalian tissues. These include heart, skeletal muscle, kidney, adrenal, liver, thyroid, and blood.
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