Abstract
Four phenolic compounds were isolated from the roots of Sanguisorba officinalis L. by silica gel column chromatography and preparative HPLC. On the basis of chemical and spectroscopic methods, their structures were identified as methyl 4-O-β-D-glucopyranosy-5-hydroxy-3-methoxylbenzoate (1), 3,3′,4′-tri-O-methylellagic acid (2), fisetinidol-(4α-8)-catechin (3), and (+)-catechin (4). Compound 1 is a new phenolic glycoside and compounds 2 and 3 were isolated from the Sanguisorba genus for the first time. Compounds 1–4 were also assayed for their antioxidant activities using the DPPH free radical assay.
Highlights
Sanguisorba officinalis L. (Rosaceae) is a perennial plant widely distributed in China, and its roots have been used as a traditional Chinese medicine for the treatment of hemostasis and inflammation [1]
In order to study the mechanism of hemostasis, we have carried out the isolation and identification of bioactive constituents of the roots of S. officinalis L
In a previous paper [10], we have reported the terpenoid constituents from the roots of S. officinalis L
Summary
Sanguisorba officinalis L. (Rosaceae) is a perennial plant widely distributed in China, and its roots have been used as a traditional Chinese medicine for the treatment of hemostasis and inflammation [1]. Pharmacological studies on its hemostatic and anti-inflammatory properties have been reported [8,9], but the molecular level mechanisms of these activities have not been reported until now. In order to study the mechanism of hemostasis, we have carried out the isolation and identification of bioactive constituents of the roots of S. officinalis L. In a previous paper [10], we have reported the terpenoid constituents from the roots of S. officinalis L. As another part of our study, we Molecules 2012, 17 report in the present study the isolation and identification of a new phenolic glycoside 1, together with three phenolic compounds 2, 3 and 4, and their antioxidant activity
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