Abstract
An undescribed isocoumarin derivative, named (±)-isothielavic acid (1), was isolated from the metabolites of endophytic fungus Thermothielavioides terrestris YB4 together with two known compounds 4(S)-thielavic acid (2) and thymine (3). The structure of (±)-isothielavic acid (1) was elucidated by comprehensive analysis of NMR spectroscopy and HRESIMS data as well as single-crystal X-ray diffraction experiment. Bioassay results indicated the weak antibacterial activity of compound 1in vitro.
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