Abstract
A new metabolite of vitamin D 3 has been isolated in pure form from incubations of rat kidney homogenates with 25-hydroxyvitamin D 3 [25-OH-D 3]. It was identified as 23,25-dihydroxy-24-oxo-vitamin D 3 [23,25(OH) 2-24-oxo-D 3] by means of ultraviolet absorption spectrophotometry and mass spectrometry. Also, 25-OH-D 3-26,23-lactone and 24R,25-dihydroxyvitamin D 3 were obtained from the same incubation mixtures. The enzyme activity responsible for the conversion of 25-OH-D 3 to 23,25(OH) 2-24-oxo-D 3 was induced by perfusion of the kidneys in vitro with 50 nM 1,25-dihydroxyvitamin D 3 [1,25(OH) 2D 3].
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