Isolation and Evaluation of Mucilage of Adansonia digitata Linn as a Suspending Agent.

S D Kadam,S S Deshmukh,S S Shyale,Y S Katare,D A Landge,D V Shah,J B Pawar,S S Bhujbal

doi:10.1155/2013/379750

Abstract

Natural excipients can serve as alternative to synthetic products because of local accessibility, biodegradability, eco-friendly nature and cost effectiveness as compared to synthetic products. Therefore, it is a current need to explore natural excipients that can be used as an effective alternative excipient for the formulation of pharmaceutical dosage forms. Adansonia digitata (Malvaceae) has been traditionally used as febrifuge, antiasthmatic and also in the treatment of dysentery, smallpox, and measles. Reports have indicated that mucilage of the leaves of the plant is edible and nontoxic; hence, the present study is an attempt of isolation and evaluation of mucilage obtained from leaves of Adansonia digitata as suspending agent. Various physicochemical as well as suspending agent properties of mucilage were studied. Mucilage obtained from leaves has shown comparable results with sodium carboxy methyl cellulose.

Highlights

Natural polymers have been used in different pharmaceutical formulations
The Leaves of Adansonia digitata were collected from Ahmednagar, Maharashtra, India, and authenticated by Senior Botanist, Department of Botany, MJS College, Maharashtra, India
The leaves of Adansonia digitata were dried, powdered, and sieved through number 120. 100 gm of the undersized powder particles was mixed with 500 mL of distilled water and allowed to settle for 24 h

Summary

Introduction

Plant-derived polymers such as mucilages can occur in high amounts in different parts of the plant and have evoked tremendous interest due to their diverse pharmaceutical applications such as diluent, binder, disintegrant in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels, and bases in suppositories. They are used in cosmetics, textiles, paints, and paper making. Because of its strategic location, geographically and environmentally, has been traditionally a good source for such products amongst the Asian countries [3]

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Conclusion