Abstract
Methylsulfonyl (MeSO 2) metabolites of polychlorobiphenyl (PCBs) have been shown to be present in humans, in tissues of animals fed with PCBs and in relatively high levels in free living animals such as otter and seals. In addition, serious effects of these compounds have been reported in mice. It is therefore necessary to develop analytical methods for the determination of MeSO 2-PCBs, which can be applied for monitoring purposes. In this contribution the incorporation of the determination of MeSO 2-PCBs in an existing multiresidue method for the determination of chlorinated and brominated pollutants is reported. Aromatic MeSO 2 compounds dissolve in sulphuric acid. In the multiresidue method, sample extracts are initially cleaned up with sulphuric acid. The resulting acid layer, which is usually discarded, contains the MeSO 2 compounds, which are isolated by additional liquid liquid extraction and adsorption chromatography using aluminiumoxide and silica. Recoveries of this procedure for 6 MeSO 2-PCBs and MeSO 2-DDE are in the 75–100% range. The method was applied to Grey seal and otter tissue and White-tailed eagle eggs. Results show intra- and interspecies differences in the patterns of MeSO 2 compounds. It is estimated that levels of MeSO 2-PCBs can amount to between 2 and 10 % of the total PCB levels present in mammals.
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