Abstract
Megakaryocyte (MK) precursor cells correspond to a spectrum of cells extending from an early progenitor to the promegakaryoblast, a 2N cell that switches from a mitotic to an endomitotic process (). The MK progenitors express the CD34+ antigen and are either CD38– or CD38+, depending upon their maturation stage. The most primitive progenitors (BFU-MK and the mixed erythro-MK progenitors) are negative for CD38, while the others are CD38 positive (). Other differentiation markers, such as HLA-DR or AC133 (,), have also been used to study MK differentiation. In the adult, CD41 (platelet GPIIb) appears during differentiation and can be used to select a subset of MK progenitors that essentially correspond to the more mature MK progenitors and promegakaryoblasts. In contrast, CD41 is more widely expresssed on neonatal hematopoietic progenitors. CD42 has a slightly later expression than CD41 (5), although after the beginning of CD42 synthesis, expression levels of CD41 and CD42 are well correlated. Thus, MK differentiation may proceed by different stages: CD34+CD38–CD41–, CD34+CD38+CD41–, CD34+CD38+CD41+CD42–, CD34+CD41+CD42+, CD34–CD41+CD42+, CD34–CD41+++CD42+++ (Fig. 1). Open image in new window Fig. 1. Expression of different markers during MK differentiation. See introduction for further explanation.
Published Version
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