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Abstract
Bacteroides fragilis is the predominant member of the group of fecal microflora and is also frequently cultured from the normal female urogenital tract. Infections with this organism occur when predisposing events such as intraabdominal pathology and gastrointestinal or genitourinary surgery lead to a breakdown of normal anatomic barriers. Clinical isolates are frequently resistant to several drugs. Because of the well-established role of R-factor plasmids in the mediation of resistance of gram-negative aerobes to one or several antibiotics [1], it was of interest to examine B. fragilis, an obligately anaerobic gram-negative bacillus, for the presence of plasmids. This report describes the detection by dye-buoyant densityequilibrium centrifugation of plasmid DNA in the form of covalently closed circular (CCC) DNA molecules in B. fragilis. The plasmid DNA was characterized by density velocity sedimentation and by electron microscopy. The presence of the plasmids was not correlated with any obvious resistance to antibiotics in these host strains.
Published Version
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