Abstract
Rabbit colostrum contains a minimum of four proteins also present in serum. These proteins are tentatively identified by immunoelectrophoresis as albumin, transferrin, IgG and IgA. IgA is present in colostrum in much greater quantities than in serum and may be isolated from the whey fraction of colostrum by gel filtration on Sephadex G-200. This IgA has the immunoglobulin allotype antigenic specificities controlled by both the (a) (H chain) and (b) (L chain) loci. Antigenic determinants of the L chain of IgA are also present in IgA; some H chain determinants may shared by IgA and IgA; while no determinants in common are demonstrable. Crude estimation of the mol. wt. of colostral igA by gel filtration gives an approximate value of 300,000–500,000, which suggests that colostral IgA exists primarily a polymeric form.
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