Abstract
Aim To study the chemical constituents of the venom of Conus betulinus that collected from South China Sea. Methods Gel chromatography and HPLC were applied to isolate toxins from the venom of Conus betulinus and a peptide toxin was obtained. Its chemical structure was characterized by mass spectrometry, amino acid analysis, N-terminal sequence and disulfide location. The structure was validated by comparison with natural and synthetic compounds. Results A conotoxin named conotoxin bt5a was isolated from the venom of Conus betulinus and its sequence is H-Ser-Gla-Cys-Cys-Ile-Arg-Asn-Phe-Leu-Cys-Cys-OH, in which Cys 3 and Cys 10, Cys 4 and Cys 11 form two intrachain disulfide bonds. Conclusion Conotoxin bt5a is a new member of T-superfamily conotoxins.
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