Abstract
Four bacteriophages recognizing the Escherichia coli capsular antigens K3, K7, K12, and K13, respectively, were isolated from pooled sewage samples. The nucleic acid of these phages was identified as double-stranded DNA of different size (phi K3, 71.3; phi K7, 32.8; phi K12, 42.9; phi K13, 43.4 kbp). Three of these phages belonged to Bradley's morphology group C and were specific for K3, K7, and K12 antigens, respectively. The phage phi K13 (Bradley's group A) attacked not only E. coli K13 strains but also E. coli producing the closely related K20 and K23 antigens. It is suggested that the common basic repeating units occurring in these capsular polysaccharides are the primary receptor of phi K13. It could be demonstrated that the four phages were able to depolymerize enzymatically the capsular polysaccharides isolated from the respective host strains.
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