Abstract
Sialic acids are a group of about 30 closely related sugars derived from neuraminic acid. The most frequently occurring members of this family are N-acetylneuraminic acid (Neu5Ac) > N-glycolylneuraminic acid (Neu5Gc) > N-acetyl-9-0-acetylneuraminic acid (Neu5,9Ac2) > N-glycolyl-9-0-acetylneuraminic acid (Neu9Ac5Gc) > N-acetyl-4-0-acetylneuraminic acid (Neu4,5Ac2). As sialic acids are in most cases linked to the terminal position of carbohydrate chains and are thus the first molecules to be recognized from outside of e.g. a cell, they may influence the interaction of cells with other cells or molecules (see this volume, Schauer & Reuter). Consequently, modification of sialic acids as e.g. 0-acetylation is expected to alter these interaction phenomena and other properties of sialic acids.
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