Abstract
Background Determining the infarct-related artery in STEMI during a coronary angiogram can be challenging due to the affliction of multiple vessels. Isolated STEMI involving only EKG leads I and aVL is infrequent. Localization of infarct-related artery based on EKG findings has not been previously done in this subset. Methods All consecutive de novo acute coronary syndrome (ACS) patients admitted to coronary care unit with ST elevations involving only leads I and aVL were screened for enrollment. Patients with ST elevation in any additional lead and those who refused a coronary angiogram were excluded. Subsequently, a coronary angiogram was done as part of primary PCI or a pharmacoinvasive approach to identify the infract-related artery (IRA). IRA was defined by characteristics of lesion, flow of blood through stenosis, and presence of intracoronary thrombus. Coronary angiogram was interpreted by two independent observers blinded to the EKG findings. ST changes in inferior and precordial leads were analyzed to find ECG predictors of the culprit artery. Results A total of 54 eligible patients of ACS were included in the study. The first major diagonal (D1) was the most frequent IRA in 35.2% followed by left circumflex-obtuse marginal (LCX-OM11) in 29.6%, left anterior descending (LAD) in 20.4%, and ramus intermedius (RI) in 14.8%. Out of total patients with ST depression in lead V2, the LCX-OM11 group was IRA in 50% cases while the RI, D1, and LAD groups accounted for 31.8%, 13.6%, and 4.5%, respectively (p < 0.001). Similarly, LCX-OM1 was the most frequent IRA subjects with ST depressions in leads V1 and V3 (44.4%; p = 0.010 and 46.2%; p = 0.003, resp.). On the contrary, in patients with ST depression in lead III, LAD and D1 were the most frequent IRA as compared to LCX-OM1 and RI though statistical significance was not attained (p = 0.857 for lead III). ST-segment depression in lead V2 had a positive predictive value of 60% and a negative predictive value of 100% for LCX-OM1 as IRA. Similarly, ST-segment depression in lead V2 had a positive predictive value of 20% and a negative predictive value of 100% for the RI group. Conclusions In patients presenting with isolated ST elevation in leads I and aVL, the most frequent IRA on angiogram was first diagonal. ST depressions in EKG leads V1–V3 were the most common predictor of LCX–OM1 while those in inferior leads indicated LAD-D1 as the IRA.
Highlights
Multivessel disease is a common finding in patients undergoing primary PCI for ST-Elevation Myocardial Infarction (STEMI) [1]
We hypothesized that, by identifying different EKG patterns resulting from occlusion of a particular coronary artery and its branches, we will be in a better position to predict infarct-related artery (IRA) in patients with de novo acute coronary syndrome (ACS) involving ST-segment elevation in leads I and aVL only. e ST-segment depressions in various limb and precordial leads were examined to identify a particular pattern associated with the occlusion of a coronary artery
Regarding the therapeutic strategy employed, 66.7% of patients were thrombolyzed with streptokinase and 11.1% of patients underwent primary PCI. e remaining 22.2% of patients were nonthrombolyzed because they were late presenters and did not meet the guideline-based criteria for reperfusion
Summary
Multivessel disease is a common finding in patients undergoing primary PCI for ST-Elevation Myocardial Infarction (STEMI) [1]. Two earlier studies have elaborated the EKG changes of ACS due to occlusion of the first diagonal branch [8, 9] Both these studies showed that ST-segment elevation in lead aVL was the most important EKG finding. A study by Birnbaum et al described electrocardiographic differentiation between occlusion of LAD, first diagonal, and first obtuse marginal coronary artery in patients having ACS with ST-segment elevation in lead aVL along with any other lead [10]. We hypothesized that, by identifying different EKG patterns resulting from occlusion of a particular coronary artery and its branches, we will be in a better position to predict IRA in patients with de novo ACS involving ST-segment elevation in leads I and aVL only. ST depressions in EKG leads V1–V3 were the most common predictor of LCX–OM1 while those in inferior leads indicated LAD-D1 as the IRA
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
