Abstract
BackgroundThe cardiovascular relevance of isolated low levels of high‐density lipoprotein cholesterol (HDL‐C) is yet to be determined. Stroke often leads to long‐term disability, and thus, not only stroke mortality but also stroke incidence is a topic of research. Although isolated low HDL‐C level has been found to be a predictor for stroke mortality previously, whether it can predict stroke incidence is unknown.MethodsIn the Jichi Medical School cohort study, 11 025 community‐living residents without a history of stroke were examined. Hazard ratios (HRs) for isolated and non‐isolated low HDL‐C levels were calculated relative to those for normal HDL‐C levels in stroke patients using Cox's regression models.ResultsDuring the mean follow‐up period of 10.7 years, 412 residents had their first‐ever stroke. The multivariable‐adjusted HRs for the levels of isolated and non‐isolated low HDL‐C were 1.11 (95% confidence interval, 0.85‐1.44) and 1.35 (1.01‐1.81), respectively, when compared to that for normal HDL‐C.ConclusionLow HDL‐C levels with other dyslipidemias may contribute to the incidence of stroke, not isolated low HDL‐C.
Highlights
Stroke is the most common cause of disability and mortality and is a concerning health issue worldwide.[1]
Previous studies have reported that the levels of isolated low high-density lipoprotein cholesterol (HDL-C) do not predict stroke-related mortality,[9,10] but whether it can predict the incidence of stroke remains unknown
The predictive relationship of isolated low HDL-C levels with the incidence of first-ever stroke was investigated among general Japanese residents in a cohort study
Summary
Stroke is the most common cause of disability and mortality and is a concerning health issue worldwide.[1]. Low levels of high-density lipoprotein cholesterol (HDL-C) are reported to be associated with an increased risk of stroke.[3,4,5,6,7,8] most studies did not adjusted other lipid abnormalities. The relevance of isolated low levels of HDL-C in stroke remains undetermined. Previous studies have reported that the levels of isolated low HDL-C do not predict stroke-related mortality,[9,10] but whether it can predict the incidence of stroke remains unknown. 90% of patients who experience a first-ever stroke survive the first month.[11] Factors associated with the incidence and mortality of stroke can be different. The predictive relationship of isolated low HDL-C levels with the incidence of first-ever stroke was investigated among general Japanese residents in a cohort study
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