Abstract
Insulin-dependent diabetes is a multifactorial disorder characterized by beta-cell dysfunction that results in metabolic failure. Isolated islets remain a lucrative area of diabetes research as these are miniature organ systems that are able to secrete insulin upon appropriate stimulation without nervous control. This review encompasses the mechanisms responsible for beta cell destruction and regeneration from both beta and non-beta cells. Isolated islets are potential model for in vitro antidiabetic drug development screening of antihyperglycemic agents and elucidating their mechanism of actions. In this review various protocols of islet isolation have been discussed with their relative rates of success with regard to yield purity islet health morphology and stability in culture conditions. Various islet protecting compounds of natural origin along with their mechanism of action have also been reviewed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Rajiv Gandhi University of Health Sciences Journal of Pharmaceutical Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
