Abstract
The combined prevalence of partial or complete agenesis of the corpus callosum (ACC) is estimated at 0.02-0.5%.This common brain malformation mainly due to a prenatal abnormality commissuration. We report a case of diagnosis of isolated fetal CCA. Magnetic resonance imaging appears to be an important adjunct as it allows direct visualization. The prognosis in isolated agencies of the corpus callosum remains uncertain.
Highlights
The corpus callosum is the largest commissural structure in the human brain, formed by more than 190 million cross-hemispheric axons that are known to exhibit excitatory function [1]
Magnetic resonance imaging appears to be an important adjunct as it allows direct visualization
Each case should be discussed during the pluridisciplinary prenatal diagnostic discussion and termination of pregnancy is often advised in these circumstances
Summary
The corpus callosum is the largest commissural structure in the human brain, formed by more than 190 million cross-hemispheric axons that are known to exhibit excitatory function [1]. The combined prevalence of partial or complete agenesis of the corpus callosum (ACC) is estimated at 0.02-0.5% [2]. This common brain malformation mainly due to a prenatal abnormality commissuration [1]. The corpus callosum (CC) can be assessed on ultrasound by direct visualization, or by finding of indirect signs suggestive of corpus callosum agenesis, such as moderate distension of the occipital ventricle and the ventricular communications, absence of the cavum septi pellucidi, are often the reason for detection in a screening population. Magnetic resonance imaging appears to be an important adjunct as it allows direct visualization. It can confirm ACC, assess whether this is complete or partial and detect coexisting brain abnormalities. Each case should be discussed during the pluridisciplinary prenatal diagnostic discussion and termination of pregnancy is often advised in these circumstances
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