Abstract
Aim: To investigate ventricular functions and tissue Doppler echocardiography-derived myocardial performance index and the elastic characteristics of the aorta in patients with coronary artery ectasia. Material and methods: 42 patients with coronary artery ectasia ; mean age 56.9 ± 9.1 years and 26 subjects with angiographically normal coronaries; mean age 54.1 ± 6.9 years, were included in the study. All the subjects underwent echocardiography and tissue Doppler imaging to determine left ventricular diastolic functions, myocardial performance index, and elastic characteristics of the aorta Results: The LV diastolic functions and myocardial permanence were impaired in the ectasia group as compared with patients with normal coronary arteries. The values obtained for aortic elasticity, as aortic strain, β index and aortic distensibility were lower in the ectasia group when compared with the values of the normal group Conclusion: Left ventricular myocardial performance index, and elasticity of the aorta were deteriorated in patients with isolated coronary ectasia.
Highlights
Isolated coronary artery ectasia (CAE) is localized or diffuse dilation of epicardial coronary arteries, 1.5 times the diameter of the adjacent normal coronary segment without any specific symptoms [1,2,3]
Atherosclerosis, congenital causes, inflammatory or connective tissue disorders are among the probable etiologic factors; exact pathophysiologic mechanism remains unclear despite some molecular, cellular and vascular mechanisms defined in various studies [5,6]
Sex, body mass index, diabetes mellitus, dyslipidemia, family history, and smoking status did not differ between the CAE patients and the control group
Summary
Isolated coronary artery ectasia (CAE) is localized or diffuse dilation of epicardial coronary arteries, 1.5 times the diameter of the adjacent normal coronary segment without any specific symptoms [1,2,3]. It is either congenital or acquired and its incidence is reported to be between 0.3 - 10% in different studies [1,4,5]. The left ventricular functions and diastolic parameters of a small set of patients with CAE and no obstructive coronary artery disease have been evaluated by conventional and tissue Doppler echocardiography (TDE) and compared to controls [16]. Right ventricular function, which is a prognostic indicator for most heart diseases [17,18], has not been studied in patients with CAE
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