ISOLATED CAT HEAD PERFUSION BY DONOR DOG.

Abstract

IN A preceding study,4it was shown that a cat head, isolated completely by the method of Hirsch et al,5continued to have unchanged circulation, and unchanged frequency and amplitude of the electroencephalogram (EEG) for one to two hours when perfused with disc oxygenated dog blood, provided the screen filtration pressure (SFP) of the dog blood was kept normal by filtering it through Pyrex glass wool. With increase in the SFP of the perfused blood, the circulation to the isolated cat head decreased and the EEG became isoelectric. These experiments raise the question of the mechanism of compatibility of blood from different species of animals and may be of importance in the problem of organ transplantation, In many of the experiments just cited, agglutination of mixed dog and cat blood occurred. Yet after filtration of this blood through Pyrex glass wool, the agglutination either disappeared or decreased sufficiently